How do locomotor neuronal circuits shape animal behaviors?
- GENETIC PATHWAYS
- NEURONAL IDENTITIES
- LOCOMOTOR CIRCUIT DEVELOPMENT
- ANIMAL BEHAVIORS
In the end we expect to apply the lessons from studying model organisms for developing ways to help people with motor function defects such as spinal cord injuries and ALS.
Molecular Logic of Spinocerebellar Tract Neuron Diversity and Connectivity. Baek M, Menon V, Jessell TM, Hantman AW, Dasen JS. Cell Reports. 2019; 27(9):2620-2635. ISSN: 2211-1247.Learn more
Looking for Graduate students (MS, PhD, MS-PhD).
Before Semester starts, you could have a chance to experience our lab through Internships.
Please find Admission guide Here:Admission guide
During locomotion, motor neurons are activated in a rhythmic and patterned manner. The motor neuron activites are under the control of locomotor circuits in the spinal cord, where motor neurons receive diverse inputs including sensory inputs, local interneuron inputs, desending inputs from the brain.
In the end, we aim to apply the lessons from these studies to developing ways to help people affected by motor function defects such as spinal cord injuries and ALS.
For achieving these scientific goals, we are applying Cutting edge molecular, genetic, developmental, and neurogenetic tools to Diverse model organisms including mouse, chicken, and skate.
The news in The New York Times explains what we are doing and where we are going:New York Times
Yoo, D. A., Park, J., Lee, C., Song, I., Lee, Y. H., Yun, T., Lee, H., Heguy, A., Han, J. Y., Dasen, J. S., Kim, H., & Baek, M. (2022, October 26). Little skate genome provides insights into genetic programs essential for limb-based locomotion. eLife. Retrieved October 27, 2022, from https://elifesciences.org/articles/78345
Yun, T., Shin, S., Bang, K., Lee, M., Cho, J. A., & Baek, M. (2021). Skin Wound Healing Rate in Fish Depends on Species and Microbiota. International journal of molecular sciences, 22(15), 7804.
Baek M, Menon V, Jessell TM, Hantman AW, Dasen JS. Molecular Logic of Spinocerebellar Tract Neuron Diversity and Connectivity. Cell Reports. 2019; 27(9):2620-2635. ISSN: 2211-1247.
Guan W., Venkatasubramanian L., Baek M, Mann RS, Enriquez J. Visualize Drosophila Leg Motor Neuron Axons Through the Adult Cuticle. J Vis Exp. 2018(140). ISSN: 1940-087X
Jung H*, Baek M*, D’Elia KP, Boisvert C, Currie PD, Tay B-H, Venkatesh B, Brown SM, Heguy A, Schoppik D, Dasen JS. The Ancient origins of neural substrates for land walking. Cell. 2018; 172(4):667- 682. * co-first authors. ISSN: 0092-8674.
Sweeney LB, Bikoff JB, Gabitto MI, Brenner-Morton S, Baek M, Yang JH, Tabak EG, Dasen JS, Kintner CR, Jessell TM. Origin and Segmental Diversity of Spinal Inhibitory Interneurons. Neuron. 2018 ;97(2):341-355. ISSN: 0896-6273.
Baek M, Pivetta C, Liu J-P, Arber S, Dasen JS. Columnar-intrinsic cues shape premotor input specificity in locomotor circuits. Cell Reports. 2017;21(4):867-77. ISSN: 2211-1247.
Dimidschstein J, Chen Q, Tremblay R, Rogers SL, Saldi GA, Guo L, Xu Q, Liu R, Lu C, Chu J, Grimley JS, Krostag AR, Kaykas A, Avery MC, Rashid MS, Baek M, Jacob AL, Smith GB, Wilson DE, Kosche G, Kruglikov I, Rusielewicz T, Kotak VC, Mowery TM, Anderson SA, Callaway EM, Dasen JS, Fitzpatrick D, Fossati V, Long MA, Noggle S, Reynolds JH, Sanes DH, Rudy B, Feng G, Fishell G. A viral strategy for targeting and manipulating interneurons across vertebrate species. Nat Neurosci. 2016;19(12):1743-9. ISSN: 1097-6256.
Enriquez J, Venkatasubramanian L, Baek M, Peterson M, Aghayeva U, Mann RS. Specification of individual adult motor neuron morphologies by combinatorial transcription factor codes. Neuron. 2015;86(4):955-70. ISSN: 0896-6273.
Baek M, Enriquez J, Mann RS. Dual role for Hox genes and Hox co-factors in conferring leg motoneuron survival and identity in Drosophila. Development. 2013;140(9):2027-38. ISSN: 0950-1991.
Baek M, Mann RS. Lineage and birth date specify motor neuron targeting and dendritic architecture in adult Drosophila. J Neurosci. 2009;29(21):6904-16. ISSN: 0270-6474.
Lee S, Lee H-S, Baek M, Lee D-Y, Bang Y-J, Cho H-N, Lee Y-S, Ha J-H, Kim H-Y, Jeoung D-I. MAPK signaling is involved in camptothecin-induced cell death. Molecules & Cells. 2002;14(3). ISSN: ISSN: 1016-8478.
Jeoung D, Kim J-H, Lee Y-H, Baek M, Lee S, Baek N-I, Kim H-Y. cDNA microarray analysis of transcriptional response to hyperin in human gastric cancer cells. Journal of microbiology and biotechnology.
Lee H, Lee S, Baek M, Kim H-Y, Jeoung D-I. Expression profile analysis of trichostatin A in human gastric cancer cells. Biotechnology Letters. 2002;24(5). ISSN: 0141-5492.
Jeoung D, Oh S-J, Lee S, Baek M, Lee Y-H, Baek N-I, Kim H-Y. Microarray analysis of piceatannol-induced changes in gene expression in human gastric cancer cells. Biotechnology letters. 2002;24(6):463-7. ISSN: 0141-5492.
Lee S, Baek M, Kim H-Y, Ha J-H, Jeoung D-I. Mechanism of doxorubicin-induced cell death and expression profile analysis. Biotechnology Letters. 2002;24(14):1147-51. ISSN: 0141-5492.
Lee S*, Baek M*, Yang H, Bang Y-J, Kim WH, Ha J-H, Kim D-K, Jeoung D-I. Identification of genes differentially expressed between gastric cancers and normal gastric mucosa with cDNA microarrays. Cancer letters. 2002;184(2):197-206. * co-first authors. ISSN: 0304-3835.
If you're interested in our lab, please contact Prof. Myungin Baek. It is highly recommened to send a copy of your personal statement and transcript to Prof. Baek before applying to school.